Declining frequency of liver enzyme abnormalities with statins: experience from general practice in Jerusalem.

Objective: Safety data of statins have been collected from diverse ethnic populations. Drug effects, including adverse reactions, may depend on genetics and environment. We investigated liver enzymes in relation to statin treatment in a northeast Jerusalem Jewish community.

Correlation between serum alanine aminotransferase activity and age: an inverted U curve pattern.

Background: Alanine aminotransferase (ALT) activity is the most widely used laboratory test for the recognition of liver disease. Normality limits for values of serum ALT activity have been questioned lately. One reason for this recent uncertainty may be an unrecognized decline in aminotransferase levels in the aging population.