DIAGNOSTICS OF OPTIC DISC DRUSEN IN CHILDREN WITH SWEPT SOURCE OCT IMAGING.

Aim: The aim of this retrospective study is to compare two methods of optic disc drusen imaging in pediatric patients - new swept source OCT technology with the B-scan ultrasonography, which has been assumed to be a gold standard in diagnosing optic disc drusen, and to compare pRNFL thickness in children with optic disc drusen and control group.

Methods: 14 eyes of 8 pediatric patients in whom optic disc drusen were confirmed by either B-scan ultrasonography, or swept-source OCT, were included in the study. We compared the sensitivity of these two imaging methods.

[Deep perforating trabeculectomy--results after up to six years follow-up].

Aim: The aim of this retrospective study was to establish intraocular pressure (IOP) values in patients after deep perforating trabeculectomy (TE) in time periods after the surgery (one month, 3 months, 1 year, 3 years, and 6 years). Furthermore, the pharmacotherapy after TE and complications after TE, especially consecutive cataract surgeries, were followed-up.

Material And Methods: Altogether 110 patients were included into the study, which underwent TE in the years 2003 - 2008 at the Department of Ophthalmology, Kyjov Hospital, Czech republic.

Initial visual acuity is an important prognostic factor in patients with branch retinal vein occlusion.

Purpose: To evaluate the role of initial visual acuity (VA) as a potential prognostic factor for final VA in patients with branch retinal vein occlusion (BRVO).

Methods: A retrospective data analysis involving 163 patients with macular edema secondary to BRVO treated according to the recommendations of the Branch Vein Occlusion Study Group was performed using univariate and multivariate logistic regression models, and receiver-operating characteristics analysis. The analyses take factors into account that can potentially influence final visual result: sex, age, type of occlusion (major temporal or macular), grid photocoagulation and ischemia.

The role of thrombophilia in patients with retinal vein occlusion and no systemic risk factors.

Objective: The role of thrombophilia in the etiology of retinal vein occlusion (rVO) has not been adequately clarified. The aim of this study was to examine the prevalence of thrombophilia among RVO patients with and without systemic risk factors and among patients younger and older than 50 years.

Design: Prospective case-control study.

[The intravitreal application of the tissue plasminogen activator in the treatment of submacular hemorrhage--a case report].

The authors present the possibility to influence therapeutically the submacular hemorrhage caused by age-related macular degeneration in the presence of choroidal neovascular membrane by means of recombinant plasminogen tissue activator (rt-PA) and expansive gas intravitreal injection followed by pneumatic relocation of the hemorrhage out of the foveolar region. The therapy is presented in a case report. The submacular hemorrhage without treatment causes serious decrease of visual functions.

[Disturbances of the plasma coagulation defects in retinal venous occlusions].

Occlusions of retinal veins (central and branch) represent multifactorialy-conditioned disease involving presumably older patients, in whom the changes of retinal vessels caused by hypertension and atherosclerosis present the most important pathophysiological factors for development of this disease. In last years, the intensive scientific research is focused to the explanation of the role of the defects of the coagulations cascade. Especially in younger patients, the most often mentioned defect of the coagulations cascade is called as APC-resistance.

[Lutein and antioxidants in the prevention of age-related macular degeneration].

Demographic developments in Europe and North America are causing an increase of age-related diseases. Age-related macular degeneration (AMD) is one of the leading causes of severe central visual acuity loss in elderly people and seems to be an economic problem, too. There is evidence that oxidative damage is an important factor for exacerbation of AMD.

[Orbital apex syndrome of the aspergillus etiology--a case report].

The authors present a case report of a patient, in whom after a head injury the monolateral blindness occurred. Because of autoimmune thrombocytopeny the patient was treated with long-term corticosteroids. The clinical findings corresponded with the orbital apex syndrome.

[Functional examination of retinal vessels in patients with central retinal vein occlusion].

Retina vessel analyzer (RVA) provides the functional examination of retinal vessels based on the analysis of the extent (size) of their dilation and constriction. The RVA measures continuously on-line the diameter of retinal arteries and veins after different kind of stimulation. Beyond dynamic vessel analysis, another possibility of the RVA's utilization is a static vessel assessment, measuring the arterial and venous diameter ratio (A/V ratio), which provides the information about the rate of arterial vasoconstriction.

[Long-term functional effect of pars plana vitrectomy in complications of proliferative diabetic retinopathy].

In the years 1997-2004, we operated on and at least one year followed-up due to complication of prolipherative diabetic retinopathy 47 eyes (40 patients), of the mean age 61 years. If we compare the initial visual acuity (VA) to the vision at the last examination in the late postoperative period, or at least one year after the surgery, we may state, that in 28 eyes (60%) the vision improved, in 11 eyes (23%) VA remained stable and in 8 eyes (17%) the vision decreased. In the late postoperative period, the visual acuity 1/60 (3/200 or 0.

[Ocular sparganosis in the Czech Republic--a case report].

The authors report a case of 14-year-old boy presented to the Ophthalmologic Department of University Hospital in Olomouc with the diagnosis af acute anterior uveitis. A living parasite has been detected in the anterior chamber in a slit lamp examination. The vitreous and retina remained uninvolved.

An oral test of pancreatic chymotrypsin activity using N-acetyl-L-tyrosyl-p-amino-benzoic acid in rats.

After a single dose of up to 50 mg/kg body weight (optimal amount for the test) of p-aminobenzoic acid or the corresponding amount of synthetic chymotrypsin substrate N-acetyl-L-tyrosyl-p-aminobenzoic acid, the urinary excretion of p-aminobenzoic acid in rats increases approximately linearly during 24 h. Higher doses do not cause any further significant increase in the amount of urine excreted p-aminobenzoic acid. Compared with a 24 h collecting period, 82% of p-aminobenzoic acid and 77% of p-aminobenzoic acid from N-acetyl-L-tyrosyl-p-aminobenzoic acid were excreted in the urine during the first 6 h after oral application of these substances.