Publications by authors named "Freya Molenberghs"
Article Synopsis
- HPV vaccines are effective due to their reliance on neutralizing antibodies, and recent findings suggest HPV-specific antibodies can be found in first-void urine (FVU), presenting a less invasive method for diagnostics.
- The study examined whether HPV16-specific antibodies in FVU samples maintain neutralizing ability using two types of assays; results indicate these antibodies in FVU are indeed neutralizing, with one assay method proving more sensitive than the other.
- High correlations between HPV16-neutralizing antibodies in FVU and serum samples were found, suggesting that HPV vaccination could lower transmission risks, which supports further research and development of HPV vaccination programs.
Human papillomavirus (HPV) infection is a primary cause of cervical and head-and-neck cancers. The HPV genome enters the nucleus during mitosis when the nuclear envelope disassembles. Given that lamins maintain nuclear integrity during interphase, we asked to what extent their loss would affect early HPV infection.
View Article and Find Full Text PDFHuman papillomaviruses (HPV) are small, non-enveloped DNA viruses, which upon chronic infection can provoke cervical and head-and-neck cancers. Although the infectious life cycle of HPV has been studied and a vaccine is available for the most prevalent cancer-causing HPV types, there are no antiviral agents to treat infected patients. Hence, there is a need for novel therapeutic entry points and a means to identify them.
View Article and Find Full Text PDFConfined no more: Viral mechanisms of nuclear entry and egress.
Int J Biochem Cell Biol
December 2020
Viruses are obligatory intracellular parasites. For their efficient replication, many require access to the nuclear interior. Yet, only few viral particles are small enough to passively diffuse through the nuclear pore complexes, calling for alternative strategies to bypass the nuclear envelope barrier.
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