First-in-human phase 1 dose-escalation study of CAN04, a first-in-class interleukin-1 receptor accessory protein (IL1RAP) antibody in patients with solid tumours.

Background: Interleukin-1 (IL-1) signalling is involved in various protumoural processes including proliferation, immune evasion, metastasis and chemoresistance. CAN04 is a first-in-class monoclonal antibody that binds IL-1 receptor accessory protein (IL1RAP), required for IL-1 signalling. In this first-in-human phase 1 study, we assessed safety, recommended phase 2 dose (RP2D), pharmacokinetics, pharmacodynamics and preliminary anti-tumour activity of CAN04 monotherapy.

ICON: a randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer.

Background: Immunotherapy with checkpoint inhibitors (CPI) targeting PD-1 or CTLA-4 has emerged as an important treatment modality for several cancer forms. In hormone receptor positive breast cancer (HR + BC), this therapeutic approach is largely unexplored. We have started a clinical trial, ICON (CA209-9FN), evaluating CPI combined with selected chemotherapy in patients with metastatic HR + BC.

[Femoral neck fractures in Nord-Trøndelag 1988-95. Incidence differences between winter and sommer months].

The incidence of hip fractures among the elderly is high. Previous studies have revealed considerable geographical differences in Norway with the highest incidence of hip fractures in Oslo. Using hospital registers, we found there was an annual incidence of first-time hip fractures of 583 per 100,000 inhabitants 50 years and older in the county of Nord-Trøndelag.

Regional differences in hospital admission rates for suspected and verified myocardial infarction in Nord-Trøndelag county, Norway.

Objective: To investigate differences in the occurrences of hospitalized suspected and verified acute myocardial infarction (AMI) between the two hospital regions, Namdal and Innherred, within a single county in Norway.

Design: A descriptive epidemiological study.

Setting: The county of Nord-Trøndelag in the central part of Norway (131,000 inhabitants).

[Differences in diagnostic criteria for acute myocardial ischemia at Norwegian hospitals].

In the present study medical departments at 57 (83%) of all hospitals in Norway answered a questionnaire about the criteria used to diagnose acute myocardial infarction. One hospital specified a period of chest pain lasting over 30 minutes; 14 hospitals worked on 30 minutes and 36 hospitals based their diagnosis on a period of less than 30 minutes. Six hospitals did not use any particular duration of pain in order to make a positive diagnosis.

[Referral from general practitioner to specialist. A study from Nord-Tröndelag].

Out of 4,892 patients who visited general practitioners during a four-week period, 307 were referred to specialists (6.3%). The main reason for referral seemed to be lack of necessary knowledge.

[Opinion of patients with back pain about the treatment received. A questionnaire study].

6 1/2 years after hospitalization for low back pain 364 patients answered a questionnaire on their opinion of the help they had received. 53.5% were satisfied with the help and support provided by their general practitioner and 78.