Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells in vitro.

Neurodegenerative diseases are often accompanied by neuroinflammation and impairment of the blood-brain barrier (BBB) mediated by activated glial cells through their release of proinflammatory molecules. To study the effects of glial cells on mouse brain endothelial cells (mBECs), we developed an in vitro BBB model with inflammation by preactivating mixed glial cells (MGCs) with lipopolysaccharide (LPS) before co-culturing with mBECs to study the influence of molecules released by activated MGCs. The response of the mBECs to activated MGCs was compared to direct stimulation with LPS.

A software for testing and training visuo-motor coordination for upper limb control.

Background: Developing methods to accelerate improvements in motor function are welcomed in clinical practice. Therefore, the aim of this study is to describe changes in brain activity related to the execution of motor tasks implemented on a software - the NeuroMaze - developed specifically to stimulate speed-accuracy tradeoff.

New Method: The NeuroMaze was tested in eleven young and healthy individuals in a single experimental session.