Effectiveness and safety of endotracheal tube cuffs filled with air versus filled with alkalinized lidocaine: a randomized clinical trial.

Context And Objective: High intracuff pressure in endotracheal tubes (ETs) may cause tracheal lesions. The aim of this study was to evaluate the effectiveness and safety of endotracheal tube cuffs filled with air or with alkalinized lidocaine.

Design And Setting: This was a prospective clinical study at the Department of Anesthesiology, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista.

[Systolic pressure variation as an earlier hypovolemia indicator and a guide for volume replacement with hypertonic and hyperoncotic solution in dogs].

Background And Objectives: Studies have introduced a new method for preload evaluation based on systolic pressure variation analysis (SPV) during mechanical ventilation. This research aimed at evaluating whether SPV and its delta down derived (ddown) are earlier hypovolemia indicators and guides for volume replacement with hypertonic and hyperoncotic solutions.

Methods: Twelve dogs were submitted to graded hemorrhage of 5% of their volume until reaching 20% of volume (14 ml.