Publications by authors named "Fredrik Ginstman"
Background: Subarachnoid haemorrhage (SAH) is one of the most severe forms of stroke in which delayed cerebral ischemia is one of the major complications. Neurointensive care aims at preventing and treating such complications and identification of biomarkers of early signs of ischemia might therefore be helpful.
Methods: We aimed at describing proteome profile in cerebral microdialysate in four patients with aneurysmal SAH using two dimensional gel electrophoresis in combination with mass spectrometry in search for new biomarkers for delayed cerebral ischemia and to investigate if there were temporal fluctuations in those biomarkers over time after aneurysmal bleed.
Article Synopsis
- Traumatic brain injury (TBI) is a major cause of death for young people and is increasingly common in the elderly, with Sweden reporting 20,000 new cases annually, mostly mild.
- The initial impact of TBI can lead to severe complications like brain hemorrhages and requires monitoring of consciousness levels and intracranial pressure for proper assessment.
- The primary focus of acute management is to prevent secondary injuries that can worsen the initial damage, with about 4-5% of cases necessitating surgical intervention.
Cerebral blood flow is monitored in the neurointensive care unit (NICU) to avoid further brain damage caused by secondary insults following subarachnoid hemorrhage and brain trauma. Current techniques are mainly snap-shot based and focus on larger vessels. However, continuous monitoring of the smaller vessels may help detect the onset of secondary insults at an earlier stage.
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