Publications by authors named "Fredrick Elishama Kakembo"
Article Synopsis
- - Uganda is experiencing a rising incidence of colorectal cancer (CRC), primarily affecting younger patients who often present with advanced-stage disease, highlighting a lack of genetic research in this area.
- - In a study involving 127 Ugandan CRC patients, next-generation sequencing revealed 48 mutations in the APC gene, with 9 being novel and pathogenic, along with additional variants in PIK3CA and SMAD4 genes that could significantly impact treatment strategies.
- - The research offers valuable clinicopathological data and insights into genetic variations of CRC, contributing to a greater understanding of how Ugandan CRC cases differ from those in other populations.
SARS-CoV-2 undergoes frequent mutations, affecting COVID-19 diagnostics, transmission and vaccine efficacy. Here, we describe the genetic diversity of 49 SARS-CoV-2 samples from Uganda, collected during the COVID-19 waves of 2020/2021. Overall, the samples were similar to previously reported SARS-CoV-2 from Uganda and the Democratic Republic of Congo (DRC).
View Article and Find Full Text PDFTandem repeats (TRs) represent one of the largest sources of genetic variation in humans and are implicated in a range of phenotypes. Here we present a deep characterization of TR variation based on high coverage whole genome sequencing from 3550 diverse individuals from the 1000 Genomes Project and H3Africa cohorts. We develop a method, EnsembleTR, to integrate genotypes from four separate methods resulting in high-quality genotypes at more than 1.
View Article and Find Full Text PDFTandem repeats (TRs) represent one of the largest sources of genetic variation in humans and are implicated in a range of phenotypes. Here we present a deep characterization of TR variation based on high coverage whole genome sequencing from 3,550 diverse individuals from the 1000 Genomes Project and H3Africa cohorts. We develop a method, EnsembleTR, to integrate genotypes from four separate methods resulting in high-quality genotypes at more than 1.
View Article and Find Full Text PDFBackground: Uganda remains one of the countries with the highest burden of TB/HIV. Drug-resistant TB remains a substantial challenge to TB control globally and requires new strategic effective control approaches. Drug resistance usually develops due to inadequate management of TB patients including improper treatment regimens and failure to complete the treatment course which may be due to an unstable supply or a lack of access to treatment, as well as patient noncompliance.
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