An involucrin promoter AP1 transcription factor binding site is required for expression of involucrin in the corneal epithelium in vivo.

Purpose: Cell division of corneal limbal stem cells gives rise to transient amplifying cells that ultimately differentiate to form the multilayered corneal epithelium. The mechanisms that regulate changes in gene expression during this process are not well understood. In the present study, the involucrin gene was used as a model to study this regulation.