Publications by authors named "Frederique Calligaris"
Article Synopsis
- Ritonavir (RTV) significantly enhances the levels of protease inhibitors (PIs) in plasma when used alongside another PI, but this interaction varies widely among individuals.
- A study involving 542 HIV-infected patients showed that the effectiveness and variability of PI concentrations differed based on the specific PI combined with RTV, with lower concentrations observed when APV or LPV were used compared to SQV or IDV.
- The findings emphasize the importance of personalized dose adjustments for RTV and PIs due to individual differences in drug response, which are essential to avoid treatment failure or toxicity.