Publications by authors named "Frederikke Schierbeck"
Article Synopsis
- Soluble ST2 is a prognostic biomarker for nonrelapse mortality (NRM) in patients undergoing allogeneic hematopoietic cell transplantation (HCT), with a focus on its early measurements post-transplant, but its pretransplant levels also need evaluation.
- The study examined 374 adults to see if pretransplant ST2 levels could predict 1-year NRM and related outcomes, along with investigating its associations with patient characteristics and other biomarkers.
- Findings showed that pretransplant ST2 levels averaged 20.4 ng/mL, were higher in males, and correlated with various health indicators, indicating that pretransplant ST2 levels could provide valuable prognostic information in HCT settings.
Objectives: The purpose of the study was to assess the validity of the hematopoietic cell transplantation-specific comorbidity index (HCT-CI) and of pulmonary comorbidity prior to HCT in terms of predicting non-relapse mortality (NRM) and overall survival (OS).
Methods: In this retrospective single-center study of 663 consecutive adult recipients of HCT, we stratified patients into groups by pulmonary comorbidity: low-risk, intermediate-risk, and high-risk. The predictive value of this pulmonary comorbidity score (PCS) was compared to HCT-CI.
Background: Low pre-transplantation plasma vitamin E levels have been associated with increased risk of acute graft-versus-host disease (GvHD) after myeloablative allogeneic hematopoietic cell transplantation (allo-HCT). We aimed to investigate the association between pre-transplantation plasma vitamin E levels and acute GvHD in patients undergoing allo-HCT with non-myeloablative conditioning.
Methods: In a cohort of 194 adults who underwent non-myeloablative allo-HCT at Rigshospitalet between July 2015 and December 2019, we measured pre-transplantation plasma vitamin E levels by high-performance liquid chromatography in stored plasma samples.