Publications by authors named "Frederik Stettler"
Article Synopsis
- Schistosomiasis impacts over 250 million people, especially affecting those aged 10-14 years, leading to uncertain liver damage severity based on the host's age.
- In a study using male mice of different ages, researchers found that older hosts showed improved outcomes in liver-related issues like inflammation and fibrosis after infection compared to younger hosts.
- The results highlight the importance of understanding how age influences liver damage and response to schistosomiasis, supporting the need for further research in patients.
Article Synopsis
- - Schistosomiasis, caused by parasitic worms, affects over 250 million people and primarily impacts the gastrointestinal tract, triggering a specific immune response linked to the formation of granulomas through its eggs.
- - A study on hamsters explored the connection between the number of parasitic eggs and the immune response, analyzing egg load and cytokine expression in liver and colon tissues.
- - Results showed no link between Th1 cytokines and egg load in the liver, while some Th2 cytokines exhibited an unexpected inverse correlation, potentially due to prolonged embryogenesis of eggs in the liver, which didn't occur in the colon.
Schistosomiasis is a parasitic disease affecting more than 250 million people worldwide. The transcription factor c-Jun, which is induced in S. mansoni infection-associated liver disease, can promote hepatocyte survival but can also trigger hepatocellular carcinogenesis.
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