Publications by authors named "Frederik Nybye Agesen"
Article Synopsis
- Sudden cardiac death accounts for 10% to 20% of deaths in Europe, prompting research to improve prediction models for at-risk individuals.
- The study used data from the Copenhagen City Heart Study (CCHS) and the Hoorn Study to validate an existing model originally developed in the USA, assessing its performance through various statistical methods.
- Findings revealed the model had good discrimination (C-statistic of 0.81) and robust calibration, but a low positive predictive value, indicating it might not effectively identify all individuals at risk in the North-West European population.
Aims: Low socioeconomic status is associated with all-cause mortality and cardiac risk factors. Furthermore, sudden cardiac death (SCD) is among the leading causes of death in the general population, and an identification of high-risk subgroups is needed. The aim of this study was to investigate the association between income and education level and incidence of SCD and to calculate the impact of modifiable mediating risk factors.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on the significant issue of sudden cardiac death (SCD) affecting many individuals, even those without apparent risk factors, and seeks to standardize the definition and classification of SCD for research purposes.
- - It establishes harmonized case definitions for SCD using multiple data sources and a register-based method, validating this approach against a comprehensive standard using factors like sensitivity and specificity.
- - The research successfully reached a consensus on classifying SCD cases as "definite," "possible," and "probable," indicating that a standardized method can support better SCD studies and allow comparison across different research cohorts.
Objective: More knowledge about the development of sudden cardiac death (SCD) in the general population is needed to develop meaningful predictors of SCD. Our aim with this study was to estimate the incidence of SCD in the general population and examine the temporal changes, demographics and clinical characteristics.
Methods: All participants in the Copenhagen City Heart Study were followed from 1993 to 2016.
Article Synopsis
- Sudden cardiac death (SCD) is a significant health issue globally, particularly affecting individuals aged 1-36 years, and this study aimed to investigate its connection with birth weight (BW) and gestational size.
- Using data from the Danish Medical Birth Register, the researchers analyzed over 2 million births from 1973 to 2008 and found that very low (<2500 g) and very high (>4500 g) birth weights were linked to a higher risk of SCD.
- The study concluded that small for gestational age (SGA) infants faced a notably increased risk of SCD and sudden arrhythmic death syndrome, emphasizing the importance of birth weight in understanding cardiac risks in young individuals.
Background Stroke is the fifth leading cause of death in young individuals globally. Data on the burden of sudden death by stroke are sparse in the young. Aims The aim of this study was to report mortality rates, cause of death, stroke subtype, and symptoms in children and young adults who suffered sudden death by stroke.
View Article and Find Full Text PDFIn this review, we evaluate the variability in the pharmacokinetics of 11 drugs with established prophylactic effects in migraine to facilitate 'personalized medicine' with these drugs. PubMed was searched for 'single-dose' and 'steady-state' pharmacokinetic studies of these 11 drugs. The maximum plasma concentration was reported in 248 single-dose and 115 steady-state pharmacokinetic studies, and the area under the plasma concentration-time curve was reported in 299 single-dose studies and 112 steady-state pharmacokinetic studies.
View Article and Find Full Text PDFBackground: Sudden cardiac death caused by coronary artery disease (CAD-SCD) is the most frequent cause of SCD in persons <50years. The aim of this study was to examine differences in clinical characteristics and autopsy findings of the heart among 18-35 and 36-49year old CAD-SCD cases.
Methods: We have previously identified all sudden cardiac deaths in Denmark through review of death certificates and autopsy reports including all deaths between 2000 and 2006 in individuals aged 18-35years and all deaths between 2007 and 2009 in individuals aged 18-49years.