Publications by authors named "Frederik A Stuebs"
Article Synopsis
- The study focuses on the diagnostic challenges of colposcopy in women aged 50 and older, particularly those with postmenopausal status and transformation zone type 3 (TZ3), highlighting the role of endocervical curettage (ECC) in diagnosing cervical lesions.
- By analyzing data from colposcopies performed at Erlangen University Hospital between 2016 and 2023, researchers correlated Pap and HPV results with histologic findings from ECC.
- The findings reveal that ECC can effectively detect significant lesions, including high-grade cervical intraepithelial neoplasia (CIN) and invasive carcinoma, even in patients with normal colposcopic results, underscoring its importance in diagnostic procedures.
Purpose: In 2018, the first guideline-based quality indicators (QI) for vulvar cancer were implemented in the data-sheets of certified gynaecological cancer centres. The certification process includes guideline-based QIs as a fundamental component. These indicators are specifically designed to evaluate the level of care provided within the centres.
View Article and Find Full Text PDFBackground/aim: The global impact of the COVID-19 pandemic resulted in disruptions to healthcare systems throughout the world. The numbers of cytology examinations, human papillomavirus (HPV) tests, and women referred for colposcopy decreased in many countries. There have been no reports on cervical cancer screening in Germany.
View Article and Find Full Text PDFVilloglandular adenocarcinoma (VGA) of the uterine cervix is a rare subtype of endocervical adenocarcinoma in young women. Between 2007 and 2020, all women with endocervical adenocarcinoma were retrospectively reviewed to find patients with VGA. Eight patients in whom pure VGA had been diagnosed were included.
View Article and Find Full Text PDF(1) Background: Vaginal intraepithelial neoplasia (VaIN) is a rare premalignant disease caused by persistent human papillomavirus (HPV) infection. Diagnosing VaIN is challenging; abnormal cytology and positive HPV tests are usually the first signs, but published data on their accuracy for detecting it are rare and contradictory. The aim of this study is to compare the results of hrHPV and cytology co-testing with the histological findings of the vagina.
View Article and Find Full Text PDFArticle Synopsis
- * It highlights a study conducted at Erlangen University Hospital, which included 5,594 patients and over 16,000 examinations in their certified dysplasia unit from July 2014 to December 2019.
- * Dysplasia units play a crucial role in managing abnormal screening results and serve as the initial contact for patients with genital issues, successfully meeting quality standards for yearly recertification.
Purpose: In 2008, the first gynecological cancer centres were certified by the German Cancer Society (DKG). Guideline-based quality Indicators (QIs) are a core element of the certification process. These QI are defined to assess the quality of care within the centres and can serve to measure the implementation of guideline recommendation.
View Article and Find Full Text PDFBackground/aim: The aims of the present study were to evaluate the accuracy of colposcopic findings, investigate the way in which untreated cervical intraepithelial neoplasia (CIN) 2/3 develops during pregnancy, and identify factors associated with regression, persistence, or progression rates.
Patients And Methods: In a tertiary gynecology and obstetrics department, 655 pregnant women were seen for colposcopy. The most common reason for referral was abnormal cytology findings.
The tumor-stroma ratio (TSR) has been repeatedly shown to be a prognostic factor for survival prediction of different cancer types. However, an objective and reliable determination of the tumor-stroma ratio remains challenging. We present an easily adaptable deep learning model for accurately segmenting tumor regions in hematoxylin and eosin (H&E)-stained whole slide images (WSIs) of colon cancer patients into five distinct classes (tumor, stroma, necrosis, mucus, and background).
View Article and Find Full Text PDFConcordance Rate of Colposcopy in Detecting Cervical Intraepithelial Lesions.
Diagnostics (Basel)
October 2022
Article Synopsis
- This research estimates the effectiveness of colposcopy in diagnosing high-grade squamous lesions and carcinomas (HSIL+) by measuring rates of concordance, sensitivity, and other predictive values over a 7.5-year period.
- A total of 4,778 colposcopies from 4,001 women were analyzed, revealing varying concordance rates for different lesion types, with the highest rates seen in more experienced examiners.
- The study highlights the importance of careful evaluation, especially for women over 35 years old with specific transformation zones, due to a higher risk of misdiagnosis.
Purpose: The aims of the present study were to evaluate the development of untreated cervical intraepithelial neoplasia (CIN) 3 during pregnancy and to assess persistence, progression, and regression rates postpartum to identify factors associated with regression.
Methods: In a tertiary gynecology and obstetrics department, a total of 154 pregnant women with CIN 3 were treated in the dysplasia unit. The follow-up findings were analyzed retrospectively on the basis of histological, cytological, and human papillomavirus (HPV) testing of 154 pregnant women confirmed as having CIN 3 in colposcopically guided biopsies.
Background: A new nationwide screening strategy was implemented in Germany in January 2020. No data are available for women referred to certified dysplasia units for secondary clarification after primary diagnosis by a local physician. We therefore investigated combined testing with Papanicolaou smears and high-risk human papillomavirus (hrHPV) and compared the data with the final histological findings.
View Article and Find Full Text PDFBackground: Approximately 4380 cases of cervical carcinoma were diagnosed in Germany in 2016. In women who had not participated in early detection programs, cervical carcinoma was usually already in an advanced stage at the time of diagnosis. Certified structures for care in conformity with the existing guidelines are available.
View Article and Find Full Text PDFArticle Synopsis
- Cervical cancer is primarily caused by persistent infections with high-risk human papillomavirus (hrHPV), and this study looked at how different hrHPV types relate to age and their association with cervical cancer and its precursor lesions.
- The research analyzed HPV samples from 652 women, finding that 30.8% were HPV-negative, with HPV-16 being the most prevalent among HPV-positive cases, especially in younger women with high-grade lesions.
- The study concluded that while HPV-16 is frequently seen in younger women (≤ 34 years), its prevalence decreases with age, highlighting the need for careful monitoring of women aged ≥ 35 who have persistent hrHPV infections due to their increased risk for developing cervical cancer.
Article Synopsis
- The study assesses how well clinical findings align with colposcopy-directed punch biopsy results for diagnosing vulvar diseases.
- Out of 482 biopsies from 420 women, the overall concordance rate between clinical observations and biopsy results was 53.9%, with higher concordance for detecting low and high-grade lesions, as well as vulvar carcinoma.
- Researchers introduced a new classification system to improve the accuracy and specificity of diagnosing vulvar lesions based on their findings.
Purpose: Malignancies of the vagina are rare, but colposcopy-directed biopsies play a major role in detecting vaginal intraepithelial lesions. Data of accuracy in detecting neoplasia of the vagina are very rare compared to accuracy in detecting cervical neoplasia. The aim of this study was to evaluate the accuracy of colposcopy-directed biopsy in comparison with clinical findings of the examiner.
View Article and Find Full Text PDFPurpose: Colposcopy-directed biopsy is a cornerstone method for diagnosing cervical intraepithelial neoplasia. The aim of this study was to evaluate the accuracy of colposcopy-directed biopsy in comparison with definitive surgery.
Methods: The accuracy of colposcopy-directed biopsy was compared with the final histology in relation to different types of transformation zone (TZ), the patient's age, and the examiner's level of training.