Publications by authors named "Frederig Lecot"
High CD8 tumour-infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neoadjuvant chemoradiotherapy.
Willem J Koemans Jolanda M van Dieren Jose G van den Berg Gerrit A Meijer Petur Snaebjornsson Frederig Lecot
Histopathology
August 2021
Article Synopsis
- - The study investigates how the tumor microenvironment and immune cell presence affect survival in esophageal adenocarcinoma (OAC) patients who poorly respond to neoadjuvant chemoradiotherapy (nCRT).
- - Researchers analyzed immune markers in tumor samples from 123 patients after nCRT, finding that high levels of CD8 immune cells negatively impacted overall survival (OS) in poor responders.
- - The findings suggest that patients with a poor response to nCRT but high CD8 counts may benefit from additional adjuvant therapy to improve their outcomes.