Publications by authors named "Frederick V Plapp"
Objective: Often in the Emergency Department (ED) of our hospital, troponin I is measured by the i-STAT (contemporary troponin I) followed by analysis of high sensitivity troponin I (hs-TnI) using the Beckman analyzer in the clinical laboratory. In this study, contemporary troponin I concentrations obtained by the i-STAT were compared with the Beckman hs-TnI concentrations in patients with myocardial infarction.
Methods: Troponin I concentrations were determined by both methods in 56 specimens collected from 56 patients admitted to the ED (time between both measurements; <1 h to up to 16 h).
Although in the majority of patients (90%), the bite wound of brown recluse spider resolves spontaneously, some patients may experience a severe reaction requiring hospitalization. A 25-year-old male developed severe hemolytic anemia, jaundice, and other complications following a brown recluse spider bite on his posterior right thigh. He was treated with methylprednisolone, antibiotics, and red blood cells (RBCs) transfusion without response.
View Article and Find Full Text PDFBackground: Immunoglobulin monoclonal light chains (MLCs) in serum and urine are markers for monoclonal gammopathy and could serve as markers of minimal residual disease (MRD) in multiple myeloma (MM). Excretion of MLCs in urine is known to result in renal damage and shorter survival in patients with LC-predominant MM.
Methods: Retrospective review of urine immunofixation in 1738 specimens at 3 medical centers was conducted to assess the utility of urinalysis for diagnosis and monitoring of monoclonal gammopathy.
Article Synopsis
- - Factor XIII deficiency is a rare bleeding disorder that can be serious if inherited; the case discussed involves a 75-year-old man with an acquired Factor XIII inhibitor treated with therapeutic plasma exchange (TPE) due to a kidney mass.
- - Six daily TPE treatments were administered to reduce bleeding risks prior to and after a kidney biopsy, with coagulation status monitored through tests like thromboelastography (TEG).
- - While TPE initially decreased the Factor XIII inhibitor titer and allowed for the successful removal of an oncocytoma, the inhibitor re-emerged months later, highlighting that TPE's effects are only temporary.