Publications by authors named "Frederick Sace"
The fibroblast growth factor receptors (FGFR) play a major role in angiogenesis and are desirable targets for the development of therapeutics. Groups of Wistar Han rats were dosed orally once daily for 4 days with a small molecule pan-FGFR inhibitor (5mg/kg) or once daily for 6 days with a small molecule MEK inhibitor (3mg/kg). Serum phosphorous and FGF23 levels increased in all rats during the course of the study.
View Article and Find Full Text PDFKidney injury biomarkers have been utilized by pharmaceutical companies as a means to assess the potential of candidate drugs to induce nephrotoxicity. Multiple platforms and assay methods exist, but the comparison of these methods has not been described. Millipore's Kidney Toxicity panel, EMD/Novagen's Widescreen Kidney Toxicity panel, and Meso Scales Kidney Injury panel were selected based on published information.
View Article and Find Full Text PDFArticle Synopsis
- A study assessed the use of the HLA-DR biomarker to identify inflammation on the ocular surface, specifically in patients with dry eye conditions.
- The assay showed strong reliability and low variability, especially within the first ten days of sample collection, but exhibited significant variability after that time.
- Results indicated that HLA-DR levels increased with the severity of dry eye disease, suggesting its potential as a useful tool in monitoring ocular surface disorders and guiding treatment development.
Objective: To evaluate the immunomodulatory effect of topical ophthalmic tofacitinib (CP-690,550) after an 8-week treatment period in patients with dry eye disease (DED).
Design: Biomarker substudy of a phase 1/2 prospective, randomized, vehicle- and comparator-controlled clinical trial (NCT00784719).
Participants: A total of 82 patients with moderate to severe DED enrolled.