Mandibular condyle erosion and sclerosis in pediatric patients treated with radiotherapy to the head and neck region.

Head and neck radiotherapy in children is associated with significant acute and late morbidities. Temporomandibular joint dysfunction and trismus has been widely reported in patients receiving radiotherapy for sarcomas and nasopharyngeal carcinoma; however, erosion of the mandibular condyle is a rare sequela of modern radiotherapy techniques. In this report, we present three cases of erosion of the temporomandibular joint amongst pediatric patients treated with radiotherapy for distinct head, neck and brain malignancies.

Transient enlargement of craniopharyngioma after radiation therapy: pattern of magnetic resonance imaging response following radiation.

Clinical experience suggests that craniopharyngiomas may temporarily increase in size after radiation therapy (RT). The study goal is to determine the incidence and natural history of this response in a cohort of patients managed at Children's Healthcare of Atlanta (CHOA) or Emory Healthcare (EHC). Between 08/1998 and 06/2009, 41 children and young adults were diagnosed with craniopharyngioma at CHOA and/or EHC.

Incidence, risks, and sequelae of posterior fossa syndrome in pediatric medulloblastoma.

Purpose: To investigate the incidence, risks, severity, and sequelae of posterior fossa syndrome (PFS) in children with medulloblastoma.

Methods And Materials: Between 1990 and 2007, 63 children with medulloblastoma at Emory University and Children's Healthcare of Atlanta were treated with craniectomy followed by radiation. Fifty-one patients were assigned to a standard-risk group, and 12 patients were assigned to a high-risk group.