Detection of new HIV infections in a multicentre HIV antiretroviral pre-exposure prophylaxis trial.

Background: Monthly specimens collected from FEM-PrEP-a Phase III trial [1] were investigated for the detection of acute HIV (AHI) infection.

Objectives: To evaluate the efficiency of the study-specific HIV algorithm in detecting AHI, and the performance of each of the serological and molecular tests used in diagnosing new infections, and their contribution to narrowing the window period.

Study Design: A total of 83 pre-seroconversion specimens from 61 seroconverters from the FEM-PrEP trial were further analyzed in a sub-study.

Performance of serological and molecular tests within acute HIV infection.

Background: Early diagnosis of acute HIV infection can be challenging and is critical in regards to early therapeutic decision making.

Objectives: To evaluate the performance of different HIV tests in detecting early infections.

Study Design: A total of 83 leftover specimens of 61 study participants who seroconverted were used in this sub-study.