Publications by authors named "Frederick Gyapon-Quast"
Article Synopsis
- Complement activation is critical in causing kidney damage in conditions like glomerulonephritis, with specific roles for complement factor H (FH) and FH-related protein 5 (FHR-5).
- FH serves to inhibit complement C3 activation, while FHR-5 can promote it by competing with FH for binding to C3b, particularly influenced by surface molecules known as glycosaminoglycans (GAGs).
- The study shows that FHR-5 binds to sulfated GAGs and enhances its competitive action against FH on C3b, which improves the understanding of how FHR-5 contributes to kidney diseases related to complement activation.
Unbiased chemoproteomic profiling of small-molecule interactions with endogenous proteins is important for drug discovery. For meaningful results, all protein classes have to be tractable, including G protein-coupled receptors (GPCRs). These receptors are hardly tractable by affinity pulldown from lysates.
View Article and Find Full Text PDFHeparan sulfate (HS) polysaccharides are ubiquitous in animal tissues as components of proteoglycans, and they participate in many important biological processes. HS carbohydrate chains are complex and can contain rare structural components such as N-unsubstituted glucosamine (GlcN). Commercially available HS preparations have been invaluable in many types of research activities.
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