Measurement of desorption rates from octadecylsilyl bonded-phase HPLC particles and its characterization in terms of pore, surface, and film diffusion.

An instrument is developed to measure rates of desorption of solutes from particulate HPLC packing materials for processes that are quantitatively complete in a few tenths of a second. The instrument is a modified, pressure-driven, stopped-flow device. The major modifications include positioning a very short (0.

Continuous desorption rate measurement from a shallow-bed of poly(styrene-divinylbenzene) particles with correction for experimental artifacts.

A 0.50 mm high bed, containing ca. 3 mg of the nominally non-porous poly(styrene-divinylbenzene) (PS-DVB) sorbent Hamilton PRP-infinity, is located in a valve.