Publications by authors named "Frederick Esofi"
Mansonella perstans infections are widespread in Sub-Saharan Africa and Central and South America and thus can be considered as the most prevalent parasite of man in tropical Africa. In contrast to the high prevalence, knowledge about the biology of this filarial nematode is restricted and no effective treatment regimens of this ivermectin-resistant parasite is lacking. An obstacle for the research is that M.
View Article and Find Full Text PDFIntroduction: Mouse models of human filarial infections are not only urgently needed to investigate the biology of the nematodes and their modulation of the host's immunity, but will also provide a platform to screen and test novel anti-filarial drugs. Recently, murine infection models have been stablished using immunocompromised mouse strains, whereas murine infections have not been implemented until now.
Methods: Therefore, we aim to establish experimental infections using the immunocompromised mouse strains RAG2IL-2Rγ (lack B, T and natural killer cells), IL-4Rα/IL-5 (impaired IL-4/5 signalling and eosinophil activation) and NOD.
Article Synopsis
- This study investigates the diversity, abundance, and distribution of biting midges in the Littoral Region of Cameroon, focusing on their role as vectors for a specific filarial nematode.
- Researchers collected midges using light traps and human landing catches, identifying eight species with one species being the most abundant, particularly active in the late afternoon.
- The findings indicate that this species is the primary vector for the nematode, and the study confirms that natural transmission occurs in the wild, significantly impacting health in the region.