Publications by authors named "Frederic Zysset"
Setting: A 950 bed teaching hospital in Switzerland.
Aim: To describe the result of a contact investigation among health care workers (HCW) and patients after exposure to a physician with smear-positive pulmonary tuberculosis in a hospital setting using standard tuberculin skin tests (TST) and Interferon-gamma release assay (IGRA).
Method: HCW with a negative or unknown TST at hiring had a TST two weeks after the last contact with the index case (T0), repeated six weeks later if negative (T6).
Article Synopsis
- Vaccination with the candidate TB vaccine Mtb72F/AS02 showed promise in reducing the global TB burden and was well tolerated in adults previously vaccinated with BCG or infected with Mycobacterium tuberculosis.
- In a controlled trial involving 38 adults, the vaccine induced immune responses, particularly persistent CD4(+) T-cell responses, although it was more reactive in those already infected with TB.
- No serious adverse events were reported, and further investigation into the vaccine’s effectiveness is suggested.
The genetic determinants and phenotypic traits which make a Staphylococcus aureus strain a successful colonizer are largely unknown. The genetic diversity and population structure of 133 S. aureus isolates from healthy, generally risk-free adult carriers were investigated using four different typing methods: multilocus sequence typing (MLST), amplified fragment length polymorphism analysis (AFLP), double-locus sequence typing (DLST), and spa typing were compared.
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