Fgf signaling components are associated with muscles and tendons during limb development.

Muscle-tendon interactions are important for the establishment of a functional musculoskeletal system. Fgf4 and Fgf8 are expressed in muscle and tendon boundary regions during limb development, suggesting a potential role for Fgf signaling pathway in muscle and tendon interactions. We have examined the expression of Fgf syn-expression group components during muscle and tendon formation of vertebrate limb development.