Publications by authors named "Frederic Coatleven"
Objectives: The management for isolated increased nuchal translucency (NT) in the first trimester with a normal karyotype and normal Chromosomal Microarray Analysis (CMA) is not consensual. The aim was to perform a survey among the Pluridisciplinary Centers for Prenatal Diagnosis (CPDPN) in France regarding their management of increased NT in the first trimester.
Methods: We conducted a multicenter descriptive survey between September 2021 and October 2021 among the 46 CPDPNs of France.
Article Synopsis
- - The study focused on collecting and analyzing cases of fetuses with 7q11.23 copy number variations (CNVs), specifically Williams-Beuren syndrome (WBS) and 7q11.23 duplication, to enhance understanding of their prenatal features.
- - Researchers gathered clinical and ultrasound data from 40 fetuses with WBS, finding that common issues included intra-uterine growth retardation (IUGR), cardiovascular defects, and other notable signs.
- - The findings confirm that 7q11.23 CNVs lead to a variety of prenatal presentations, with IUGR and cardiovascular issues being the most prevalent, aiming to help identify distinctive signs in affected fetuses.
Article Synopsis
- Twin pregnancies are increasing around the world, but they often lead to early births, which can cause health problems for babies.
- The study aimed to find out if using a special device called the Arabin pessary could help improve the health of babies in twin pregnancies where the mother has a short cervix.
- Researchers compared the effects of the pessary with regular care in 308 pregnancies to see if it reduced serious health issues or deaths for newborns.
Objectives: To describe our experience with prenatal counselling for surgical anomalies in a large volume center. The secondary aim is to suggest a list of prenatal abnormalities warranting counselling by a pediatric surgeon.
Methods: We reviewed all prenatal counselling consultations performed by the pediatric surgery team between January 1st, 2015 and December 31st, 2016.
Congenital abnormalities of the genitourinary tract are the most common sonographically identified malformations. Although prenatal diagnosis seldom modifies perinatal management, it can cause significant anxiety in parents. We aimed to assess how parents perceived the prenatal counseling they had received in our institution.
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- This study investigates the effectiveness of chromosomal microarray analysis (CMA) for diagnosing issues in fetuses with intrauterine growth restriction (IUGR), focusing on both isolated and associated cases.
- Out of 162 IUGR fetuses examined, 15 showed abnormal results from FISH tests, while CMA revealed pathogenic variations in 10 fetuses, all from the group with associated IUGR.
- The findings suggest that CMA is particularly useful for diagnosing associated IUGR, providing more accurate results than traditional karyotyping, but no pathogenic variations were found in the isolated IUGR cases.
Article Synopsis
- Postnatal depression (PND) affects up to 20% of new mothers and is influenced by a combination of psychological vulnerabilities and stress during pregnancy, highlighting the importance of mindfulness as a protective factor.
- This ongoing study, involving 260 women across five maternities, seeks to identify psychobiological predictors of PND by using a multidisciplinary approach that includes psychological, biophysiological, and genetic assessments from early pregnancy through 12 months postpartum.
- The research has received ethical approval and aims to share its findings through conferences and peer-reviewed journals, contributing to a greater understanding of chronic stress and PND mechanisms.
Objective: To retrospectively compare the imaging findings and the outcomes for patients with vascular uterine abnormalities (VUA) and to identify prognostic factors.
Material And Methods: Between 2007 and 2012, 38 patients with vaginal bleeding and abnormal ultrasonographic (US) findings consistent with acquired VUA were consecutively included (mean age 31.6 years, range 19-62).
The duration of pregnancy varies between 40(+0) and 41(+3) weeks. Conventionally, and essentially arbitrarily, a pregnancy is considered to be "prolonged" after 41(+0) weeks, but the infant is not considered "post-term" until 42(+0) weeks (Professional consensus). A term birth thus occurs during the period from 37(+0) to 41(+6) weeks.
View Article and Find Full Text PDFAim: The aim of this study was to compare the performance of tests based on the detection of insulin-like growth factor binding protein 1 (IGFBP-1) and placental α-microglobulin-1 (PAMG-1) in diagnosing rupture of fetal membranes (ROM) across different patient populations.
Methods: A meta-analysis was conducted on prospective observational or cohort studies investigating ROM tests based on the detection of IGFBP-1 and PAMG-1 meeting the following criteria: (1) performance metrics calculated by comparing results to an adequate reference method; (2) sensitivity thresholds of the investigated tests matching those of the currently available tests; (3) study population, as a minimum, included patients between 25 and 37 weeks of gestation. Sensitivities, specificities, and diagnostic odds ratios were calculated.
Infantile myofibromatosis, the most common fibrous tumor of infancy, occurs in solitary, multiple, and generalized forms, with similar histology but different clinicopathologic and prognostic implications. This entity is a mesenchymal disorder characterized by the proliferation of fibrous tumors in the skin, muscles, viscera, bones, and subcutaneous tissues. Visceral lesions are associated with significant morbidity and mortality, generally within the first few months of life.
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