Publications by authors named "Frederic Bourgeon"

Article Synopsis
  • - Tenacibaculum maritimum causes tenacibaculosis, a serious disease affecting a wide range of marine fish, and its genome analysis involved 25 strains, including 22 newly sequenced ones.
  • - All strains had similar genome sizes (~3.356 Mb) with 2,116 core protein-coding genes, showing moderate nucleotide diversity and a significant role of recombination in their evolution, although links to specific geographical origins still need further investigation.
  • - A new MALDI-TOF-MS typing method was developed to classify T. maritimum isolates into 20 MALDI-Types and 4 MALDI-Groups, offering a fast and cost-effective approach for large-scale epidemiological studies.
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Mechanisms for protecting spermatozoa, and the testes that produce them, from infection are essential, given the importance of these cells and organs for the fertility of the individual and perpetuation of the species. This is borne out by the publication of numerous papers on this subject over the last 50 years. We extended our work and that of others on the anti-infectious defense system of the male genital tract, using a new strategy for the direct identification of antibacterial molecules in human seminal plasma.

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Defensins are antimicrobial peptides that play a major role in innate immunity. Using reverse transcriptase-polymerase chain reaction, immunochemistry, or both, we performed a search of all presently known defensins in rat testis, epididymis, and isolated testicular cells; in mouse testis and epididymis; and in human testis and ejaculates. In the rat, all alpha- and beta-defensins except RNP-4 were expressed within the testis, whereas alpha-defensins RNP1-2, RNP-4, and beta-defensins RBD-1 and RBD-2 were present within the epididymis.

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