Publications by authors named "Fred Turya"
Article Synopsis
- Individuals with HIV and cryptococcal antigenemia face a high risk of developing cryptococcal meningitis or death, with factors like baseline CrAg titer and CRP levels being crucial for assessing outcomes.* -
- In a study of 182 participants, those with elevated CRP levels had a higher rate of meningitis or death compared to those with normal CRP levels, specifically revealing that elevated CRP impacted low CrAg titer individuals more significantly.* -
- The research indicates a complex relationship between CrAg titers and CRP levels, suggesting that future studies should further explore this interaction to improve patient risk assessments and outcomes.*
Article Synopsis
- Cryptococcal meningitis poses a significant risk for individuals with AIDS, and the study aims to evaluate if adding a high-dose of liposomal amphotericin B to fluconazole can reduce the incidence of meningitis among asymptomatic CrAg-positive individuals.
- In a trial with participants from Uganda, those with low plasma CrAg titers were given either liposomal amphotericin B with fluconazole or fluconazole alone for 24 weeks to assess meningitis-free survival.
- Results showed no significant difference in meningitis or death rates between the two groups, suggesting that for asymptomatic patients with low CrAg levels, adding liposomal amphotericin B does not improve outcomes and may lead to
Unlabelled: Cryptococcal antigen (CrAg) screening and pre-emptive antifungal therapy for people with CD4 cell counts <100 cells/μl are recommended by the World Health Organization and several national HIV guidelines. We sought to evaluate CrAg screening program implementation across Uganda, in relation to health center level and distance from the capital. We conducted a cross-sectional study of 22 health centers across southern Uganda from April to June 2019.
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- Cryptococcal antigen screening can help prevent meningitis and death in HIV-infected individuals with low CD4 counts, but fluconazole therapy alone is often insufficient.
- A study tested sertraline as an adjunct treatment for asymptomatic cryptococcal antigenemia among Ugandans, but it was halted early due to safety concerns, specifically related to serious adverse events (SAEs).
- While meningitis-free survival rates were similar between the sertraline and placebo groups, there were notable occurrences of psychosis and serotonin syndrome linked to sertraline, leading to concerns about its safety rather than its efficacy.