Spikes with and without concurrent high-frequency oscillations: Topographic relationship and neural correlates using EEG-fMRI.

Objective: Epilepsy surgery is the best therapeutic option for patients with drug-resistant focal epilepsy. During presurgical investigation, interictal spikes can provide important information on eligibility, lateralisation and localisation of the surgical target. However, their relationship to epileptogenic tissue is variable.

Functional connectivity of the irritative zone identified by electrical source imaging, and EEG-correlated fMRI analyses.

Objective: The irritative zone - the area generating epileptic spikes - can be studied non-invasively during the interictal period using Electrical Source Imaging (ESI) and simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI). Although the techniques yield results which may overlap spatially, differences in spatial localization of the irritative zone within the same patient are consistently observed. To investigate this discrepancy, we used Blood Oxygenation Level Dependent (BOLD) functional connectivity measures to examine the underlying relationship between ESI and EEG-fMRI findings.

Postural change in convulsive seizures: a retrospective review of video-electroencephalographic recordings.

Background: Prone position has been identified as an important risk factor for sudden unexpected death in epilepsy raising the possibility of avoidance of this posture in sleep as a preventative measure.

Aims: To evaluate the potential utility of prone posture position, we studied patterns of postural change during generalised tonic clonic seizures.

Methods: Video-electroencephalographic recordings of patients undergoing investigations at the Royal Brisbane and Women's Hospital between 2005 and 2013 were reviewed independently by two raters.

Effects of prolonged repetitive stimulation of median, ulnar and peroneal nerves.

It is important to know the effects of prolonged repetitive nerve stimulation (RNS) when it is used in neurophysiological studies. RNS with up to 100 supramaximal stimuli was given to the median, ulnar, and peroneal nerves of normal subjects and the ulnar nerves of subjects with early amyotrophic lateral sclerosis (ALS), recording evoked compound muscle action potentials (CMAPs). In all nerves, there was a decline in the CMAP area and a decrease in CMAP duration.