A pictorial review of complications of acute coalescent mastoiditis.

This case study highlights the extracranial and intracranial manifestations of severe otomastoiditis. A 35-year-old man presented with numerous symptoms, including ear and neck pain, headache, temporary vision loss, fever, malaise, and nausea and vomiting. Imaging studies led to the diagnosis of coalescent mastoiditis with septic dural sinus thrombosis, venous hemorrhagic infarctions, brain abscesses, and subdural empyema.

The development of antibiotic resistant organisms with the use of ototopical medications.

Objective: There is growing concern over the use of systemic antibiotics and the development of bacterial resistance. The question remains as to whether ototopical medications may also promote antibiotic-resistant organisms, either on a local level (in the ear) or in other areas of the aerodigestive tract. We performed an evidence-based review to answer the following clinical question, "Do antibiotic ototopical medications induce antibiotic resistant organisms?"

Study Design: We performed a MEDLINE search of the published literature from 1966 to the present.

Ototoxicity of ototopical antibiotic drops in humans.

Objective: We sought to determine the incidence of injury to the cochlea or vestibular system from the use of ototopic antibiotic ear drops.

Study Design: We conducted a MEDLINE search of the published literature from 1966 to the present using the search items of "ototopic antibiotics," "ototopic drops," "antibiotic resistance," and others to identify pertinent articles. These articles were reviewed and graded according to evidence quality.

Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects.

Objective: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans.

Study Design: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated.