Inverse association between brown adipose tissue activation and white adipose tissue accumulation in successfully treated pediatric malignancy.

Background: Although the accumulation of white adipose tissue (WAT) is a risk factor for disease, brown adipose tissue (BAT) has been suggested to have a protective role against obesity.

Objective: We studied whether changes in BAT were related to changes in the amounts of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in children treated for malignancy.

Design: We examined the effect of BAT activity on weight, SAT, and VAT in 32 pediatric patients with cancer whose positron emission tomography-computed tomography (PET-CT) scans at diagnosis showed no BAT activity.

Function and well-being in ambulatory children with cerebral palsy.

The purpose of this study was to determine whether there is a significant association between function and well-being in children with cerebral palsy. To determine this, the authors used validated measures of function (Gillette Functional Assessment Questionnaire, Gross Motor Function Classification System, Gross Motor Function Measure, and walking speed) and correlated them to health-related quality of life (HRQOL) measures (Pediatric Outcomes Data Collection Instrument, Pediatric Quality of Life instrument). In a cross-sectional study of ambulatory children with mild to moderate cerebral palsy aged 10.

Activity sampling in the assessment of patients with total joint arthroplasty.

Quantitative assessment of patient activity is important in evaluating the outcomes of joint prostheses, and such methods are gaining popularity. The single greatest impediment to quantitative activity assessment is patient compliance. How many days of sampling are necessary to provide reliable and accurate estimates of walking activity? The current study analyzes how well sampling for 4 consecutive days of activity compares to assessing activity for 7 or more days with the same pedometer in 131 patients with either a total hip or total knee prosthesis.

Metal-on-metal surface arthroplasty with a cemented femoral component: a 7-10 year follow-up study.

Forty-two McMinn metal-on-metal surface arthroplasties were implanted in 23 males and 16 females, average age 47.5 years old. The overall survivorship at 7 years was 79%; with any reoperation surgery as endpoint, 80%; and 93%; with aseptic loosening of the socket and femoral component, respectively.