Publications by authors named "Fred Hyde"
The microbiota that colonize the human gut and other tissues are dynamic, varying both in composition and functional state between individuals and over time. Gene expression measurements can provide insights into microbiome composition and function. However, efficient and unbiased removal of microbial ribosomal RNA (rRNA) presents a barrier to acquiring metatranscriptomic data.
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- Viral genome sequencing has enhanced our understanding of SARS-CoV-2's genetic diversity and spread during the COVID-19 pandemic, traditionally done through patient nasopharyngeal swabs.
- Recent advancements include using RT-qPCR on municipal wastewater to measure SARS-CoV-2 levels and metatranscriptomic sequencing to analyze viral diversity in communities.
- In the San Francisco Bay Area, sequencing sewage samples revealed SARS-CoV-2 genotypes matching local clinical samples, showing wastewater analysis can detect new viral variants earlier than traditional clinical methods.