Poly(8-aminoguanylic acid): formation of ordered self-structures and interaction with poly(cytidylic acid).

Poly(8-aminoguanylic acid) has in neutral solution a novel ordered structure of high stability. The 8-amino group permits formation of three hydrogen bonds between two residues along the "top", or long axis, of the purines. The usual hydrogen bonding protons and Watson-Crick pairing sites are not involved in the association.

Poly(8-bromoadenylic acid): synthesis and characterization of an all-syn polynucleotide.

Poly(8-bromoadenylic acid) (poly(8-BrA)) has been synthesized by polymerization of 8-BrADP with polynucleotide phosphorylase in the presence of oligonucleotide primers. In the absence of oligonucleotides, significant (i.e.

Dental health status of third grade children and their families within the context of a community's dental health care system.

Utilizing structure, process, and outcomes as conceptual dimensions of appraisal of quality, data were analyzed to present an evaluation of the quality of a community's dental health care system as reflected in a population subgroups' dental health status. Data were collected from 838 Caucasian third-graders and their parents through interviews, mail questionnaires, and dental screening examinations. Indicators of structure were: status of community water fluoridation in the study community, dentist to population ratio, and dental care resources in the public sector available to eligible residents.

The ultrastructure of lymphoblastoid cell lines from Marek's disease lymphomata.

The ultrastructure of two lymphoblastoid cell lines derived from Marek's disease lymphomata has been studied. The cells varied from 5 to 12 mum in diameter and had large round or oval nuclei. A nucleolus was occasionally present and about 3% of cells showed projections of the nuclear envelope.

T-lymphoblastoid cell lines from Marek's disease lymphomas.

The establishment and continuous culture of two lymphoblastoid cell lines derived from Marek's disease lymphomas is described. Although the cells carried T-lymphocyte surface antigens, they had many features in common with cultured Burkitt's lymphoma lymphoblasts, which carry B-cell determinants. A small proportion acted as infectious units in tissue culture, and a similarly small proportion contained intranuclear immature herpesvirus particles.

Characterization of a new serotype of Marek's disease herpesvirus.

The HPRS-24 strain of Marek's disease herpesvirus was selected for closer study from a group of virus isolates that appeared apathogenic under standard test conditons. Protection studies revealed an immunological relationship between this virus strain and acute Marek's disease herpesvirus. In chicken kidney cell cultures, the HPRS-24 strain caused small and slowly developing plaques, and the proportion of infected cells was less than with other strains.