Publications by authors named "Fraser S McIntosh"
Article Synopsis
- The study investigates the role of muscarinic receptor subtype-1 (M1) in chronic pain using the drug xanomeline, which targets both M1 and M4 receptors.
- Xanomeline effectively reduced pain sensitivity in rat and mouse models, specifically reversing issues like tactile allodynia and heat hyperalgesia due to neuropathic and inflammatory pain.
- The analgesic effect of xanomeline was blocked by nonselective antagonists (scopolamine and pirenzepine) and significantly reduced by the selective M1 receptor toxin (MT-7), indicating that M1 receptors play a crucial role in pain relief, while M4 receptors are less significant.
