The dietary flavonol quercetin ameliorates angiotensin II-induced redox signaling imbalance in a human umbilical vein endothelial cell model of endothelial dysfunction via ablation of p47phox expression.

Scope: Quercetin is reported to reduce blood pressure in hypertensive but not normotensive humans, but the role of endothelial redox signaling in this phenomenon has not been assessed. This study investigated the effects of physiologically obtainable quercetin concentrations in a human primary cell model of endothelial dysfunction in order to elucidate the mechanism of action of its antihypertensive effects.

Methods And Results: Angiotensin II (100 nM, 8 h) induced dysfunction, characterized by suppressed nitric oxide availability (85 ± 4% p<0.

Aspartame sensitivity? A double blind randomised crossover study.

Background: Aspartame is a commonly used intense artificial sweetener, being approximately 200 times sweeter than sucrose. There have been concerns over aspartame since approval in the 1980s including a large anecdotal database reporting severe symptoms. The objective of this study was to compare the acute symptom effects of aspartame to a control preparation.

The Occurrence, Fate and Biological Activities of C-glycosyl Flavonoids in the Human Diet.

The human diet contains a wide variety of plant-derived flavonoids, many of which are glycosylated via an O- or less commonly a C-glycosidic linkage. The distribution, quantity, and biological effects of C-glycosyl flavonoids in the human diet have received little attention in the literature in comparison to their O-linked counterparts, however, despite being present in many common foodstuffs. The structural nature, nomenclature, and distribution of C-glycosyl flavonoids in the human diet are, therefore, reviewed.

Caffeoylquinic acids and flavonoids in the immature inflorescence of globe artichoke, wild cardoon, and cultivated cardoon.

The species Cynara cardunculus is consumed as part of the Mediterranean diet and consists of the globe artichoke [var. scolymus (L.) Fiori], the cultivated cardoon (var.

The C-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans.

Human bioavailability of the flavonoid dihydrochalcones is little understood, and no evidence exists for C-glycosyl flavonoid absorption in humans. The present study uses catechol-O-methyltransferase to generate methylated metabolites of aspalathin (a C-glycosyl dihydrochalcone from rooibos tea). One of the methylated forms, both with and without glucuronidation, was detected using LC-MS/MS in the urine of human subjects (n = 6), demonstrating that deglycosylation is not a prerequisite for C-glycosyl flavonoid absorption.