Synthesis, radiofluorination, and preliminary evaluation of the potential 5-HT receptor agonists [ F]Cimbi-92 and [ F]Cimbi-150.

An agonist PET tracer is of key interest for the imaging of the 5-HT receptor, as exemplified by the previously reported success of [ C]Cimbi-36. Fluorine-18 holds several advantages over carbon-11, making it the radionuclide of choice for clinical purposes. In this respect, an F-labelled agonist 5-HT receptor (5-HT R) tracer is highly sought after.