Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers.

YAP activation in cancer is linked to poor outcomes, making it an attractive therapeutic target. Previous research focused on blocking the interaction of YAP with TEAD transcription factors. Here, we took a different approach by disrupting YAP's binding to the transcription factor B-MYB using MY-COMP, a fragment of B-MYB containing the YAP binding domain fused to a nuclear localization signal.

Profile of Athletes With a Vision Impairment: Exploring Demographics and Ocular Pathologies of Athletes in Three Paralympic Sports.

Objective: This study aimed to explore the profile of athletes with a vision impairment who compete in three Paralympic sports (goalball, vision impairment judo, and blind football).

Design: Descriptive and association analyses of the vision impairment athletes' profile were conducted.

Results: The typical athlete profile was a male (65.

Impact of Running With and Without a Guide on Short Distance Running Performance for Athletes With a Vision Impairment.

Objective: This study aimed to investigate the difference of running with or without a guide on running performance (100, 200, and 400 m) for athletes with a vision impairment.

Design: Data including athletes' and guides' sex, age, and race times were extracted from 11 elite competitions.

Results: Male athletes predominantly ran without a guide (100 m = 91.

Evidence-based Classification in Track Athletics for Athletes with a Vision Impairment: A Delphi Study.

Significance: The Delphi analysis presented here highlights the need for a sport-specific evidence-based classification system for track athletics for athletes with a vision impairment (VI). This system may differ for different race distances. Further research is required to develop a useful test battery of vision tests for classification.