Annual Papanicolaou screening for 5 years among human papillomavirus-negative women.

Background: Primary human papilloma virus (HPV) screening is more effective than cytology in reducing the risk of cervical cancer, but screening intervals should be extended in HPV-negative women. However, some Markov models predicted that long intervals are associated with an excess risk of cervical cancer. The aim of this analysis was to estimate the real-life risks and benefits of annual Papanicolaou (Pap) screening in HPV-negative women with normal cytology.

The First Description of Docetaxel-Induced Recall Inflammatory Skin Reaction After Previous Drug Extravasation.

Objective: To describe a cutaneous recall soft tissue injury at the site of previous extravasation of docetaxel.

Case Summary: A 65-year-old white female with an invasive ductal carcinoma of the right breast was treated with carboplatin AUC 2 and docetaxel 30 mg/m(2) weekly via a peripheral vein access. During the 14th cycle, drug extravasation of docetaxel occurred in the left antecubital fossa characterized by a mild erythema without edema.