Publications by Franziska Mau

Publications by authors named "Franziska Mau"

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Programmed Death-Ligand 1 (PD-L1) Expression Is Induced by Insulin in Pancreatic Ductal Adenocarcinoma Cells Pointing to Its Role in Immune Checkpoint Control.

Steffen M Heckl Franziska Mau Anke Senftleben Tina Daunke Silje Beckinger

Med Sci (Basel)

June 2021

Type-2 diabetes (T2DM) is a risk factor for the development of pancreatic ductal adenocarcinoma (PDAC) and is characterized by insulin resistance and hyperinsulinemia. Besides the well-known growth-promoting activity of insulin or the other members of the Insulin/Insulin-like Growth factor (IGF) axis, we here describe an inducing effect of insulin on PD-L1 expression in PDAC cells. Treatment of the PDAC cell lines BxPc3, A818-6, and T3M4 with insulin increased PD-L1 expression in a time- and dose dependent fashion, as shown by Western blot and qPCR analysis.

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- Franziska Mau's research focuses on the interplay between insulin signaling and immune checkpoint regulation in pancreatic ductal adenocarcinoma (PDAC) cells, particularly in the context of type-2 diabetes (T2DM).
- The study reveals that insulin can induce the expression of Programmed Death-Ligand 1 (PD-L1) in PDAC cell lines, potentially contributing to immune evasion in the presence of hyperinsulinemia, which is a characteristic of T2DM.
- Findings suggest a novel mechanism by which insulin may influence tumor immunology, indicating that treatment strategies targeting both insulin pathways and PD-L1 expression could be beneficial in PDAC management.

Publications by authors named "Franziska Mau"

Programmed Death-Ligand 1 (PD-L1) Expression Is Induced by Insulin in Pancreatic Ductal Adenocarcinoma Cells Pointing to Its Role in Immune Checkpoint Control.

Synopsis of recent research by authors named "Franziska Mau"