German Parents and Educators of Two to Four-Year-Old Children as Informants for the Strengths and Difficulties Questionnaire (SDQ).

Screeners are used in early intervention and early childhood education and care programs to identify children's potential need for further evaluation and diagnostics. The Strengths and Difficulties Questionnaire (SDQ) is a brief behavioral screening instrument that can be completed by both parents and educators to assess the social and emotional traits of children. However, multiple informants' reports vary.

Families with young children during the COVID-19 pandemic-The importance of family type, perceived partnership roles, parental stress, and social support for changes in the home learning environment during lockdown.

Beginning in March 2020, the lockdown precipitated by the COVID-19 pandemic resulted in many challenges, especially for families with young children. Many children had little or no access to institutional education. Therefore, they were even more dependent on their parents providing them with home learning activities (HLA) to support their development.

Changes in Parents' Home Learning Activities With Their Children During the COVID-19 Lockdown - The Role of Parental Stress, Parents' Self-Efficacy and Social Support.

As a result of the abrupt closures of daycare centers in Germany due to the COVID-19 pandemic, parents' ability to provide learning opportunities at home became all the more important. Building on the family stress model, the study investigates how parental stress affected changes in parents' provision of home learning activities (HLA) during the lockdown, compared to before the lockdown. In addition, the study considers parental self-efficacy and perceived social support as protective factors that may play important roles in disrupting the negative effects of stress.

[(Digital) parent-educator cooperation in preschool during Corona pandemic. Digitization boost or missed opportunity?].

The closure of day-care centres as a measure to contain the corona virus presented early childhood educators with changed working conditions and opportunities to implement the continuing educational mandate. The cooperation between parents and educators, including through digital tools, plays an important role in this respect. The paper examines a) how often and of what type early childhood educators implemented digitally supported parental cooperation during the closure of day-care centres, b) which attitudes educators had towards general as well as digitally supported parental cooperation, and c) what role their qualifications, their attitudes and their perceived support through the centre played for their digital and non-digital parental cooperation during the closure of day-care centres.

Longitudinal Effects of the Family Support Program Chancenreich on Parental Involvement and the Language Skills of Preschool Children.

When they enter primary school children already vary significantly in their language skills, depending at least in part on their family's social background. In particular, the home learning environment plays a significant role in children's development. For that reason, early intervention programs have been developed to obviate learning difficulties and to promote health, children's development, and educational equality.

Correction: High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.

Since the publication of this article, the authors have found that the numbers of patients and controls were reversed. This study included 412 MS patients and 419 controls. This correction applies to the Abstract, the final paragraph of the Introduction, and the first paragraph of the Materials and Methods.

High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.

We investigated association between HLA class I and class II alleles and haplotypes, and KIR loci and their HLA class I ligands, with multiple sclerosis (MS) in 412 European American MS patients and 419 ethnically matched controls, using next-generation sequencing. The DRB1*15:01~DQB1*06:02 haplotype was highly predisposing (odds ratio (OR) = 3.98; 95% confidence interval (CI) = 3-5.

The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia.

Killer cell immunoglobulin-like receptors (KIRs), via interaction with their cognate HLA class I ligands, play a crucial role in the development and activity of natural killer cells. Following recent reports of KIR gene associations in childhood acute lymphoblastic leukemia (ALL), we present a more in-depth investigation of KIR genes and their cognate HLA ligands on childhood ALL risk. Genotyping of 16 KIR genes, along with HLA class I groups C1/C2 and Bw4 supertype ligands, was carried out in 212 childhood ALL cases and 231 healthy controls.