Clinical Course, Genetic, and Immunohistochemical Characterization of Solid Pseudopapillary Tumor of the Pancreas (Frantz Tumors) in a Brazilian Cohort.

Frantz tumors or solid pseudopapillary pancreatic neoplasm (SPN) are rare exocrine neoplasms that carry a favorable prognosis; they represent up to 3% of all tumors located in the region of the pancreas and have specific age and gender predispositions. In recent years, the rising curve of diagnosis is entitled to the evolution and access of diagnostic imaging. In this paper, we have retrospectively reviewed and described the clinical course of 40 patients with SPN from three institutions in Brazil, who had their diagnosis between 2005 and 2020, and analyzed the clinicopathological, genetic, and surgical aspects of these individuals.

Ethyl-pyruvate reduces lung injury matrix metalloproteinases and cytokines and improves survival in experimental model of severe acute pancreatitis.

Purpose: To investigate if the ethyl-pyruvate solution could reduce mortality in AP and/or diminish the acute lung injury.

Methods: Forty male rats, weighing between 270 to 330 grams were operated. An experimental model of severe AP by injection of 0.

Severe acute pancreatitis: results of treatment.

Objective: To evaluate the results of the Protocol for treatment of patients with severe acute pancreatitis.

Methods: We consecutively analyzed age, gender, etiology, length of hospital stay, type of treatment and mortality of 37 patients with severe acute pancreatitis from January 2002.

Results: The patients' ages ranged from 20 to 88 years (average 50 years), 27% were female and 73% male.

Castleman's disease mimetizing pancreatic tumor.

Context: Angiofollicular lymph node hyperplasia or Castleman's disease is a rare clinical condition. Knowledge about etiology and physiopathology; and treatment management as well are yet to be defined. Unicentric presentation of this disease affecting single lymph nodes in the mediastinum seems to be the most common presentation.

Expression of p53, p16 and Ki67 proteins in ductal adenocarcinoma of the pancreatic head and their relation with survival and cell differentiation.

Objective: To determine the expression of p53, p16 and Ki-67 and its relevance in survival and cell differentiation.

Methods: Fifteen duodenopancreatectomized patients were included. Immunohistochemical expression of p53, p16 and Ki-67 was determined in paraffin embedded tumor blocks.

Evaluation of the effects of noniodinized and iodinized ionic contrast media and gadoteric acid in acute necrotizing pancreatitis: experimental study in rabbits.

Objective: To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis.

Methods: Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was induced through retrograde injection of 5% sodium taurocholate (1 mL/kg weight) in the main pancreatic duct. After 3 hours, they were randomized to receive endovenous iodinized nonionic contrast medium (group 1), iodinized ionic contrast medium (group 2), gadoteric acid (group 3), and physiological serum at 0.

[Pancreatic insulinomas].

Insulinoma is the most frequent neuroendocrine pancreatic tumor. In the present study, the clinical and immunohistochemical results of 20 patients who underwent surgery between January 1986 and December 2004 were evaluated. Clinical presentation, laboratory data, imaging studies, aspects of the surgical technique, complication rates and medium- and long-term follow-up were analyzed.

[Pancreatic insulinomas: diagnosis and treatment].

Background: Despite its rarity, the insulinoma is the most common pancreatic neuroendocrine tumor.

Objective: Analyze clinical and immunohistochemical data from surgical resection of the pancreas insulinoma.

Method: Twelve cases are described, concerning surgical aspects, complications and medium-long term outcome of patients.