Publications by authors named "Franz G M Poch"
Article Synopsis
- The study aimed to explore computed tomography-based thermography (CTT) for predicting ablation zones during microwave ablation (MWA) in a porcine liver model.
- CTT effectively visualized ablation zones, showing a significant correlation between CT attenuation values and temperature changes, implying that the technique can be used to accurately assess treatment areas.
- The findings suggest that CTT could be beneficial in clinical settings to improve patient outcomes and potentially reduce the risk of local cancer recurrence.
Article Synopsis
- The study investigated how nearby blood vessels impact the effectiveness of microwave ablation (MWA) in liver tissue, using ex vivo experiments on pig liver.
- Significant cooling effects were noted when vessels were close to the MWA antenna (5-10 mm), particularly with vessels of 3 mm or larger that had blood flow rates of 1 mL/min or more.
- The findings suggest that while nearby vessels can cool the area during ablation, the proximity of the antenna to the vessel is the most critical factor, and treatment plans should account for these cooling effects.
Article Synopsis
- The study evaluates the effectiveness of hepatic microwave ablation (MWA) using ex vivo porcine livers to compare macroscopic versus microscopic assessments of cell viability in ablation zones.
- Histological analysis revealed two zones: a central white zone (WZH) lacking cell viability, and a peripheral red zone (RZH) showing some viability, with significant discrepancies in size between these zones identified.
- Results highlight that relying solely on macroscopic evaluation may underestimate the extent of irreversible cell destruction during MWA, as the visible ablation zone (WZM) is smaller than the actual necrotic area (WZH).
Article Synopsis
- Radiofrequency ablation (RFA) is a treatment for liver tumors that can't be surgically removed; using a technique called the Pringle maneuver (PM) can help grow the size of ablations but may cause tissue damage.
- The study tested different PM techniques on porcine livers, comparing continuous PM, intermittent PM, and no PM to see how they affected the size of the ablations.
- Results showed that intermittent PM didn't reduce ablation size compared to continuous or no PM, and it even increased the ablation area when there was an initial flow before applying the PM.
Article Synopsis
- Multipolar radiofrequency ablation (RFA) is tested in porcine livers to improve treatment for primary liver tumors and metastases by achieving larger ablation zones.
- The study analyzed how varying applicator distances and energy inputs affected the size of ablation areas, finding that larger ablations were limited by other factors rather than just distance.
- Results indicated that while increasing energy input led to a larger radius of the ablation zone at extreme levels, minor deviations in chosen parameters did not significantly impact the final ablation size.
Article Synopsis
- Ongoing research aims to improve the safety of radiofrequency ablation (RFA) for liver tumors using animal models, focusing on understanding the accuracy of ablation zone observations.
- The study involved performing RFA on domestic pigs' livers and analyzing the results through both photography and histological techniques, measuring cell viability in the resulting ablation zones.
- Findings revealed three distinct ablation zones with strong correlations between macro and micro-morphological data, demonstrating the ability to differentiate between non-viable (white zone) and various viable cell areas (red zones) in the liver tissue after RFA.
Article Synopsis
- The study aimed to assess vascular cooling effects in multipolar radiofrequency ablation (RFA) compared to conventional methods, particularly focusing on their impact on ablation shapes and areas.
- Multipolar RFA was tested ex vivo using porcine liver, and various configurations of applicators were employed alongside a simulated vessel to evaluate cooling effects.
- Results indicated that while cooling effects were observed around perfused vessels, they did not significantly alter the overall ablation area, but did affect the shape of the ablation zone.
Minimal vascular flows cause strong heat sink effects in hepatic radiofrequency ablation ex vivo.
J Hepatobiliary Pancreat Sci
August 2016
Article Synopsis
- The study evaluates how low vascular flow rates affect cooling in bipolar radiofrequency ablation (RFA) in pig liver samples.
- Flow rates as low as 1 ml/min created a noticeable cooling effect, with the maximum impact observed at 10 ml/min.
- It suggests that even minimal blood flow can hinder RFA effectiveness, highlighting the need for precautions when performing RFA near liver blood vessels.