Range-scalable distributed acoustic sensing with EDFA repeaters demonstrated over 2227 km.

We demonstrate a new, to the best of our knowledge, range-scalable repeatered distributed acoustic sensing (DAS) solution sharing technology with existing long-haul subsea telecom networks capable of low noise and high spatial and temporal resolution. Single ended DAS interrogation through a 2227 km line comprising 39 repeatered fiber spans is demonstrated with a 10 m spatial resolution, a 1.78 kHz sampling rate, and a strain resolution of 35 pε/√Hz for the outermost span.

Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes.

Using luminescent conjugated polyelectrolyte probes (LCPs), we demonstrate the possibility to distinguish amyloid-beta 1-42 peptide (Abeta1-42) fibril conformations, by analyzing in vitro generated amyloid fibrils of Abeta1-42 formed under quiescent and agitated conditions. LCPs were then shown to resolve such conformational heterogeneity of amyloid deposits in vivo. A diversity of amyloid deposits depending upon morphology and anatomic location was illustrated with LCPs in frozen ex vivo brain sections from a transgenic mouse model (tg-APP swe) of Alzheimer's disease.