Transcription Factor ZNF281: A Novel Player in Intestinal Inflammation and Fibrosis.

Recent evidences reveal the occurrence of a close relationship among epithelial to mesenchymal transition (EMT), chronic inflammation and fibrosis. ZNF281 is an EMT-inducing transcription factor (EMT-TF) involved in the regulation of pluripotency, stemness, and cancer. The aim of this study was to investigate , and a possible role of ZNF281 in the onset and progression of intestinal inflammation.