Publications by authors named "Frans Alderse-Baas"
Circulating white blood cells and platelets amplify oxidative stress in heart failure.
Alexander J J Ijsselmuiden René J P Musters Gijsbert de Ruiter Loek van Heerebeek Frans Alderse-Baas
Nat Clin Pract Cardiovasc Med
December 2008
Background: Mitochondria of circulating white blood cells (WBC) and platelets sense oxidative stress during capillary passage and react by producing reactive oxygen species (ROS). Although evidence indicates that congestive heart failure (CHF) is associated with oxidative stress, the role of WBC and platelets as mediators in CHF has not been investigated.
Methods: Patients with CHF (n = 15) and healthy volunteers (n = 9) were enrolled between 2006 and 2007 into this observational study.