Publications by authors named "Franklyn Hall"
Marfan Syndrome, a connective tissue disorder caused by Fibrillin-1 (FBN1) gene mutations, induces disease in the ocular, musculoskeletal, and cardiovascular systems and increases aortic vulnerability to rupture associated with high mortality rates. We describe an induced pluripotent stem cell line (HFD1) generated from patient-derived human dermal fibroblasts harboring a heterozygous c.3338-2A>C intronic splice acceptor site variant preceding Exon 28 of FBN1.
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- Researchers are focusing on controlling oxygen levels in engineered systems to study their effects on cell behavior, especially under hypoxic conditions.
- A specialized hydrogel allows for precise manipulation of oxygen concentrations, enabling uniform cell behavior analysis and the study of vasculogenesis (new blood vessel formation) under different oxygen levels.
- The findings highlight the role of cyclic AMP signaling and cell adhesion molecules in endothelial cell clustering in response to oxygen deprivation, paving the way for better understanding of cellular processes in various biological contexts like regeneration and disease.
Vascular morphogenesis is the formation of endothelial lumenized networks. Cluster-based vasculogenesis of endothelial progenitor cells (EPCs) has been observed in animal models, but the underlying mechanism is unknown. Here, using O-controllabe hydrogels, we unveil the mechanism by which hypoxia, co-jointly with matrix viscoelasticity, induces EPC vasculogenesis.
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