Publications by authors named "Franklin Marques"
The use of DOX (doxorubicin), an antibiotic used in oncological treatments, is limited by a dose-related cardiotoxicity against which acute exercise is protective. However, the mitochondrial-related mechanisms of this protection remain unknown. Therefore the present study aimed to determine the effects of an acute endurance exercise bout performed 24 h before DOX treatment on heart and liver mitochondrial function.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how long-term severe hyperglycaemia affects mitochondrial function in rat skeletal muscle, specifically looking at the gastrocnemius muscle's mitochondrial bioenergetics and MPTP susceptibility.
- Sixteen male Wistar rats were split into control and diabetic groups, with diabetes induced through a single dose of streptozotocin; various mitochondrial functions were assessed 18 weeks later.
- Results indicated that diabetic rats show decreased respiratory control ratio and reduced susceptibility to MPTP opening, suggesting that the effects of hyperglycaemia on mitochondria are specific to the time and type of muscle.
Background: High-altitude hypoxia may induce oxidative stress in humans. However, the effect of acute, severe, and non-acclimatized short-term hypobaric hypoxia exposure in humans has not been described. Additionally, little is known regarding the confounding role of reoxygenation in the extent of oxidative stress and damage markers in hypoxia.
View Article and Find Full Text PDF