Objectives: To conduct cost-utility and budget impact analysis of providing Continuous Positive Airway Pressure (CPAP) therapy versus no treatment for moderate to severe obstructive sleep apnea (OSA) in Colombia from a third-party payer perspective.
Methods: We used a Markov model to assess the cost-utility and budget impact analysis of CPAP in patients over 40 years old with moderate to severe OSA. Data on effectiveness and utility values were obtained from published literature.
The Liver-Expressed Antimicrobial Peptide 2 (LEAP-2) has emerged as an endogenous GHS-R antagonist and blunts the orexigenic action of ghrelin. This study aimed to determine the Ghrelin/LEAP-2 ratio in humans and rats during pregnancy. In humans, we conducted a nested case-control study within an observational prospective cohort.
View Article and Find Full Text PDFCells
July 2022
(1) Background: Fibroblast growth factor 21 (FGF-21) is an endocrine factor involved in glucose and lipid metabolism that exerts pleiotropic effects. The aim of this study was to investigate the serum FGF-21 profile in healthy and mild preeclamptic pregnant women at each trimester of pregnancy; (2) Methods: Serum FGF-21 levels were determined by ELISA in a nested case-control study within a longitudinal cohort study that included healthy (n = 54) and mild preeclamptic (n = 20) pregnant women, women at three months after delivery (n = 20) and eumenorrheic women during the menstrual cycle (n = 20); (3) Results: FGF-21 levels were significantly lower in the mid-luteal phase compared to the early follicular phase of the menstrual cycle in eumenorrheic women (p < 0.01).
View Article and Find Full Text PDFIntroduction: Currently, daytime sleepiness is a prevalent condition worldwide. Locally validated instruments for measuring sleepiness are required. The objective of this study was to validate a version of the Karolinska sleepiness scale that was translated into the Spanish spoken in Colombia.
View Article and Find Full Text PDFThe current COVID-19 pandemic is a public health emergency that has seriously affected mental health in the general population. Both, studies on previous epidemics and those conducted during the current pandemic have reported a wide range of psychosocial consequences and multiple psychological symptoms as a result of said outbreaks, and among these problems, sleep/wake cycle alterations stand out. Publications addressing this phenomenon have consistently reported that nearly a third of people who experience social isolation develop insomnia, which, in turn, is an important predictor for mental disorders that affect people's functionality, including anxiety disorders, depression and post-traumatic stress disorder.
View Article and Find Full Text PDFIntroduction: The airport of Bogotá lies within the city and its expansion could produce an increase in adverse effects on the health of the inhabitants of Fontibón and Engativá districts due to the noise it generates.
Objective: To determine the prevalence of sleep disturbances and associated factors among residents of Fontibón exposed to this noise.
Materials And Methods: A cross-sectional study design was used, involving a sample of 205 people aged 18 to 65, selected by means of stratified random sampling.
Purpose: The severity of obstructive sleep apnoea (OSA) ranges from mild or moderate to severe sleep apnoea. However, there is no information available on the clinical characteristics associated with cases involving more than 100 events per hour. This is a preliminary report and our goal was to characterise the demographics and sleep characteristics of patients with Extreme OSA and compare with patients with sleep apnoea of lesser severity.
View Article and Find Full Text PDFRev Fac Cien Med Univ Nac Cordoba
September 2015
Restless legs syndrome is a disorder associated with the imperative need to move the legs, starting at different times of day and it gets worse at night, relieved by activity, affecting the quality of life and sleep who sufferers it. Despite being a common disorder at any age, in adults with a prevalence of up to 10%, is not diagnosed by doctors and first level specialists that is why diagnostic and therapeutic interventions get delayed contributing to the perpetuation of symptoms and worsening quality of life. Since its diagnosis is purely clinical, getting familiar with this disorder is essential to ensure proper focus and thus rule out other diseases commonly confused with this one.
View Article and Find Full Text PDFObjective: To estimate the prevalence of insomnia complaints in a population of alcoholics hospitalized in addiction clinics in Bogotá.
Method: Alcoholic patients hospitalized for detoxification in addiction clinics were recruited.
Design: observational, descriptive and cross-sectional study.
Objective: Validating the Epworth sleepiness scale (ESS-VC) for use in Colombia .
Methods: Individuals were included who consulted sleep centres in Bogotá, Pereira and Cali ( Colombia ). Study design consisted of eight phases: a pilot study for assessing the Spanish version of the scale, translation and retro-translation of the original ESS, a pilot test for evaluating understanding (n=20), validating appearance (experts, n=18), internal consistency (n=120), validating concurrent and discriminating criteria (n=150) with parallel polysomnography, reproducibility (n=15) and sensitivity to change (n=100).
Curr Opin Psychiatry
September 2005
Purpose Of Review: Forensic psychiatric examinations have gained increasing importance in many areas of the law. When individuals refuse to undergo court-ordered examinations of this kind, experts have to solve the tension between ethical and technical problems and judicial requirements. The purpose of this review is to obtain research information and standards related to refusal to undergo court-ordered forensic psychiatric examinations.
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