Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury.

Objective: In this study we have used O positron emission tomography, brain tissue oxygen monitoring, and cerebral microdialysis to assess the effects of cerebral perfusion pressure augmentation on regional physiology and metabolism in the setting of traumatic brain injury.

Design: Prospective interventional study.

Setting: Neurosciences critical care unit of a university hospital.

Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates.

Objective: To investigate the effect of hyperventilation on cerebral blood flow in traumatic brain injury.

Design: A prospective interventional study.

Setting: A specialist neurocritical care unit.