Publications by authors named "Franki Vetrano-Olsen"
Article Synopsis
- Brugada syndrome, primarily caused by loss-of-function variants, has only about 20% of cases explained by known genetic factors; recent studies point to the role of microtubule dynamics in the syndrome.
- Researchers used CRISPR/Cas9 to create a knockout zebrafish model and conducted various experiments like voltage mapping, ECG, and immunocytochemistry to evaluate cardiac function.
- Findings showed that knockout hearts had impaired electrical activity and disorganized cell junctions, with a notable improvement when adjusting microtubule dynamics through targeted interventions.
