Publications by authors named "Franka Witthauer"
Article Synopsis
- Viral mutations are a growing issue as they may reduce the effectiveness of current SARS-CoV-2 vaccines, highlighting the need for second-generation vaccines that can target conserved regions in the virus.
- Researchers immunized mice with various sarbecovirus receptor-binding domains to discover antibodies that target these critical sites, finding that while some antibodies were broadly reactive, they did not neutralize the virus effectively.
- The study identified that potent neutralizing antibodies against SARS-CoV-2 variants were linked to specific structural features, particularly a longer antibody segment that blocks virus interactions with human cells, paving the way for improved vaccine strategies.
